Macrophages (OmpA) Binds to and Activates Human Cutting Edge: Outer Membrane Protein A
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منابع مشابه
Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors.
Outer membrane protein A (OmpA) is a conserved major component of the outer membrane of Enterobacteriaceae. Here, we report that OmpA from Klebsiella pneumoniae (KpOmpA) activates macrophages and dendritic cells (DCs) in a TLR2-dependent way. However, TLR2 does not account for binding of KpOmpA to innate immune cells. KpOmpA binds the scavenger receptors (SRs) LOX-1 and SREC-I, but not other me...
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